DPP9
Gene Ontology Molecular Function
DMTN
Gene Ontology Biological Process
- actin cytoskeleton organization [ISS]
- actin filament bundle assembly [IDA, TAS]
- actin filament reorganization [ISS]
- calcium-mediated signaling using extracellular calcium source [ISS]
- calcium-mediated signaling using intracellular calcium source [ISS]
- cellular response to cAMP [IDA]
- cellular response to calcium ion [ISS]
- cytoskeleton organization [TAS]
- erythrocyte development [ISS]
- negative regulation of cell-substrate adhesion [ISS]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of protein targeting to membrane [ISS]
- negative regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of blood coagulation [ISS]
- positive regulation of fibroblast migration [ISS]
- positive regulation of integrin-mediated signaling pathway [ISS]
- positive regulation of platelet aggregation [ISS]
- positive regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of wound healing [ISS]
- protein complex assembly [IDA, ISS]
- protein secretion by platelet [ISS]
- regulation of actin cytoskeleton organization [IDA]
- regulation of cell shape [IMP]
- regulation of filopodium assembly [IMP]
- regulation of lamellipodium assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proximity labeling reveals non-catalytic interactions between DPP9 and ubiquitin signaling complexes.
Dipeptidyl peptidase 9 (DPP9) is an amino-peptidase with roles in immunity, DNA-repair, cell signaling, memory and neonatal survival; its dysregulation is linked to cancer and immune-related disorders. While many studies focus on its catalytic activity, scaffolding functions of DPP9 are emerging. Here, we mapped the DPP9 interactome using TurboID-based proximity labeling in DPP9 knock-out HEK293 cells reconstituted with doxycycline-inducible miniTurboID-DPP9, ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DMTN DPP9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9998 | BioGRID | 1192990 | |
| DMTN DPP9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9981 | BioGRID | 2234215 | |
| DMTN DPP9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9668 | BioGRID | 3144526 |
Curated By
- BioGRID