BAIT

DPP9

DP9, DPLP9, DPRP-2, DPRP2
dipeptidyl-peptidase 9
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

SHMT2

GLYA, HEL-S-51e, SHMT
serine hydroxymethyltransferase 2 (mitochondrial)
GO Process (1)
GO Function (2)
GO Component (6)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Proximity labeling reveals non-catalytic interactions between DPP9 and ubiquitin signaling complexes.

Wirtgen VE, Saied L, Zolg S, Alonso MC, Mayer B, Donzelli L, Maurer U, Timmers HTM, Knobeloch KP, Kleifeld O, Geiss-Friedlander R

Dipeptidyl peptidase 9 (DPP9) is an amino-peptidase with roles in immunity, DNA-repair, cell signaling, memory and neonatal survival; its dysregulation is linked to cancer and immune-related disorders. While many studies focus on its catalytic activity, scaffolding functions of DPP9 are emerging. Here, we mapped the DPP9 interactome using TurboID-based proximity labeling in DPP9 knock-out HEK293 cells reconstituted with doxycycline-inducible miniTurboID-DPP9, ... [more]

Cell Mol Life Sci Feb. 04, 2026; 83(1);93 [Pubmed: 41636814]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
DPP9 SHMT2
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High1BioGRID
3156433

Curated By

  • BioGRID