BAIT

NSP6

ORF1ab, ORF1ab-nsp6, SARS-CoV2 nsp6, SARS-CoV-2 nsp6, R1AB_SARS2, PRO_0000449624, GU280_gp01_nsp6
Non-structural protein 6
COVID-19 Coronavirus Project
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus 2
PREY

KIAA1715

LNP, LNP1, Ul, ulnaless
KIAA1715
GO Process (1)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

The comprehensive SARS-CoV-2 'hijackome' knowledge base.

Huuskonen S, Liu X, Poehner I, Redchuk T, Salokas K, Lundberg R, Maljanen S, Belik M, Reinholm A, Kolehmainen P, Tuhkala A, Tripathi G, Laine P, Belanov S, Auvinen P, Vartiainen M, Keskitalo S, Oesterlund P, Laine L, Poso A, Julkunen I, Kakkola L, Varjosalo M

The continuous evolution of SARS-CoV-2 has led to the emergence of several variants of concern (VOCs) that significantly affect global health. This study aims to investigate how these VOCs affect host cells at proteome level to better understand the mechanisms of disease. To achieve this, we first analyzed the (phospho)proteome changes of host cells infected with Alpha, Beta, Delta, and ... [more]

Cell Discov Dec. 09, 2024; 10(1);125 [Pubmed: 39653747]

Throughput

  • High Throughput

Additional Notes

  • SARS-CoV-2 (Wuhan-Hu-1) strain NSP6 protein S106-108del mutant (Alpha, Beta, Gamma, BA.1, BA.5-strain associated mutation)
  • SARS-CoV-2 (Wuhan-Hu-1) strain NSP6 protein wildtype

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
NSP6 KIAA1715
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High12.86BioGRID
2793701
NSP6 KIAA1715
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High60BioGRID
2807064

Curated By

  • BioGRID