An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

The comprehensive SARS-CoV-2 'hijackome' knowledge base.

Huuskonen S, Liu X, Poehner I, Redchuk T, Salokas K, Lundberg R, Maljanen S, Belik M, Reinholm A, Kolehmainen P, Tuhkala A, Tripathi G, Laine P, Belanov S, Auvinen P, Vartiainen M, Keskitalo S, Oesterlund P, Laine L, Poso A, Julkunen I, Kakkola L, Varjosalo M

The continuous evolution of SARS-CoV-2 has led to the emergence of several variants of concern (VOCs) that significantly affect global health. This study aims to investigate how these VOCs affect host cells at proteome level to better understand the mechanisms of disease. To achieve this, we first analyzed the (phospho)proteome changes of host cells infected with Alpha, Beta, Delta, and ... [more]

Cell Discov Dec. 09, 2024; 10(1);125 [Pubmed: 39653747]

Throughput

High Throughput

Additional Notes

SARS-CoV-2 (Wuhan-Hu-1) strain ORF3A protein wildtype

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ORF3A TSFM	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Jiao S (2023)	High	-	BioGRID	3754140

Curated By

BioGRID

Interaction Summary

ORF3A

TSFM

Gene Ontology Biological Process

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]

Gene Ontology Cellular Component