BAIT

ORF8

SARS-CoV2 ORF8, SARS-CoV-2 ORF8, 8, NS7B_SARS2, PRO_0000449655, GU280_gp09
Non-structural protein 8
COVID-19 Coronavirus Project
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus 2
PREY

KDELC1

EP58, KDEL1, RP11-484I6.4
KDEL (Lys-Asp-Glu-Leu) containing 1
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

The comprehensive SARS-CoV-2 'hijackome' knowledge base.

Huuskonen S, Liu X, Poehner I, Redchuk T, Salokas K, Lundberg R, Maljanen S, Belik M, Reinholm A, Kolehmainen P, Tuhkala A, Tripathi G, Laine P, Belanov S, Auvinen P, Vartiainen M, Keskitalo S, Oesterlund P, Laine L, Poso A, Julkunen I, Kakkola L, Varjosalo M

The continuous evolution of SARS-CoV-2 has led to the emergence of several variants of concern (VOCs) that significantly affect global health. This study aims to investigate how these VOCs affect host cells at proteome level to better understand the mechanisms of disease. To achieve this, we first analyzed the (phospho)proteome changes of host cells infected with Alpha, Beta, Delta, and ... [more]

Cell Discov Dec. 09, 2024; 10(1);125 [Pubmed: 39653747]

Throughput

  • High Throughput

Additional Notes

  • SARS-CoV-2 (Wuhan-Hu-1) strain ORF8 protein R52I mutant (Alpha-strain associated mutation)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ORF8 KDELC1
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
3480202
ORF8 KDELC1
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.9579BioGRID
2652605
ORF8 KDELC1
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.9579BioGRID
2875618
ORF8 KDELC1
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High-BioGRID
3580417
ORF8 KDELC1
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High10.95BioGRID
2797318

Curated By

  • BioGRID