PIP4K2A
Gene Ontology Biological Process
Gene Ontology Molecular Function
PIP5K1A
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IMP]
- activation of Rac GTPase activity [IMP]
- cell chemotaxis [IMP]
- cell migration [NAS]
- focal adhesion assembly [IMP]
- glycerophospholipid metabolic process [TAS]
- keratinocyte differentiation [TAS]
- phagocytosis [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol phosphorylation [IDA, TAS]
- phospholipid biosynthetic process [IDA]
- phospholipid metabolic process [TAS]
- protein targeting to plasma membrane [IMP]
- ruffle assembly [IMP]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks.
Phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks) have emerged as candidate drug targets in cancer, neurological, inflammatory, and infectious diseases. Although their canonical function is to phosphorylate PI(5)P to generate PI(4,5)P2, growing evidence points to additional catalytic-independent roles, but how these functions are organized within protein interaction networks remains unclear. Here, we use proximity-dependent biotin identification (BioID) in HeLa cells to map isoform-resolved interactomes ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PIP4K2A PIP5K1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2224637 | |
| PIP4K2A PIP5K1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3113650 |
Curated By
- BioGRID