BTRC
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of sequence-specific DNA binding transcription factor activity [TAS]
- negative regulation of smoothened signaling pathway [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of circadian rhythm [ISS]
- positive regulation of proteolysis [IMP]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein dephosphorylation [ISS]
- protein destabilization [IMP]
- protein ubiquitination [IDA]
- regulation of circadian rhythm [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- signal transduction [TAS]
- ubiquitin-dependent protein catabolic process [IDA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AXIN2
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IBA]
- cellular protein localization [IDA]
- cellular response to organic cyclic compound [IBA]
- dorsal/ventral axis specification [IBA]
- intramembranous ossification [IBA]
- mRNA stabilization [IMP]
- maintenance of DNA repeat elements [IMP]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of catenin import into nucleus [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of osteoblast differentiation [IBA]
- odontogenesis [IMP]
- positive regulation of GTPase activity [IBA]
- positive regulation of cell death [IMP]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of protein phosphorylation [IMP]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of mismatch repair [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation.
The DDB1- and CUL4-associated factor (DCAF) family functions as substrate receptors within Cullin4-really interesting new gene (RING) ubiquitin ligases (CRL4s), facilitating proteasomal degradation of targeted substrates. Although CRL4-based targeted protein degradation (TPD) has emerged as a promising strategy to modulate undruggable proteins, the complex formation, substrates, and functional properties of many DCAFs remain poorly defined. In this study, using proximity ... [more]
Throughput
- High Throughput
Additional Notes
- Air-ID
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BTRC AXIN2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2737012 |
Curated By
- BioGRID