BAIT

TOMM22

1C9-2, MST065, MSTP065, TOM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
Homo sapiens
PREY

TOMM40L

TOMM40B, RP11-297K8.10
translocase of outer mitochondrial membrane 40 homolog (yeast)-like
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity.

Borrero-Landazabal MA, Linke V, Kadava T, Li Z, Draczkowski P, Kaszuba K, Bertgen L, Serwa RA, Heck AJR, Chacinska A

The translocase of the outer mitochondrial membrane (TOM) is the conserved entry gate for nuclear-encoded proteins. While structurally similar from yeast to humans, the human TOM complex operates in a cellular environment of vastly greater complexity. Here, we present a high-confidence map of the human TOM interactome using a membrane-permeable cross-linker to capture both stable and transient interactors. Alongside extensive ... [more]

Sci Adv May. 01, 2026; 12(18);eaeb2995 [Pubmed: 42066079]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TOMM22 TOMM40L
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.9996BioGRID
2229433
TOMM22 TOMM40L
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High1BioGRID
3227963
TOMM22 TOMM40L
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.9505BioGRID
3027680

Curated By

  • BioGRID