An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Reduced exosomal miR-215-5p activates the NEAT1/MAPK1/p-CRMP2 pathway and contributes to social dysfunction in a VPA-induced autism model.

Liu L, Xie L, Shen Y, Zeng Z, Xu D, Bo L, Wu L, Wu Y, Zhang Y, Wang Y, Pi J, Chen X, Wang R, Yang X, Wei X, Liu H, Tang Y

Autism is a prevalent neurodevelopmental disorder characterized by social deficits. Environmental factors, such as prenatal exposure to valproic acid (VPA), are major risk factors for the development of autism in offspring. Environmental epigenetics investigates how environmental factors influence gene expression and function. Exosomal miRNAs carry epigenetic information, but their role in autism remains unknown. Here, we found that prenatal VPA ... [more]

Neuropharmacology Nov. 01, 2025; 278();110539 [Pubmed: 40466937]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
DPYSL2 DPYSL2	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Murtaza N (2022)	High	1	BioGRID	3498607

Curated By

BioGRID

Interaction Summary

DPYSL2

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]protein kinase binding [IPI]

Gene Ontology Cellular Component