Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

High Maternal Glycine Levels Increase the Risk of Developing Atrial Septal Defect in the Offspring.

Qiao YN, Chen WC, Chen YL, Xiang J, Ke YF, Cao L, Li L, Cao J, Zhao R, Zhao JY

Amino acid imbalance is linked to increased congenital heart disease risk. Here, we found women carrying rs2545801 C/C genotypes exhibited increased glycine levels and increased risk for atrial septal defects (ASDs) in their offspring. Elevated maternal glycine levels during the first trimester were correlated with a higher ASD risk in the offspring. Additionally, feeding pregnant mice with high-glycine chow increased ... [more]

JACC Basic Transl Sci Jul. 01, 2025; 10(7);101311 [Pubmed: 40561639]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
GARS DPYSL2
Co-fractionation
Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

High-BioGRID
3443451

Curated By

  • BioGRID