DLGAP2
Gene Ontology Molecular Function
GRIA2
Gene Ontology Biological Process
- establishment of protein localization [ISO]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- positive regulation of synaptic transmission [ISO]
- protein tetramerization [ISO]
- receptor internalization [ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic transmission, glutamatergic [ISO]
- synaptic transmission [IDA, ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- cell surface [ISO]
- dendrite [IBA, ISO]
- dendrite cytoplasm [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum [IDA]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [ISO]
- perikaryon [ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, IDA]
- presynaptic membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [ISO]
- terminal bouton [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dlgap2 deficiency disrupts synaptic homeostasis by promoting ubiquitin-mediated Itsn1 degradation in a valproic acid-induced autism-like model.
Prenatal valproic acid (VPA) exposure increases the risk of neurodevelopmental disorders, though its synaptic mechanisms remain unclear. Using multi-omics analyses, we identified Dlgap2 as a consistently dysregulated protein in VPA models. Mice with Dlgap2 knockdown exhibited synaptic deficits and autism-like behaviors, including social and cognitive impairments. Proteomics of postsynaptic density following Dlgap2 knockdown revealed disruption of synaptic organization and a ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIA2 DLGAP2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.2893 | BioGRID | 3498797 |
Curated By
- BioGRID