SOD2
Gene Ontology Biological Process
- age-dependent response to reactive oxygen species [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- oxygen homeostasis [IMP]
- protein homotetramerization [IPI]
- regulation of blood pressure [ISS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- release of cytochrome c from mitochondria [ISS]
- removal of superoxide radicals [IMP]
- response to superoxide [IMP]
- superoxide metabolic process [IDA]
- vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SOD2
Gene Ontology Biological Process
- age-dependent response to reactive oxygen species [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- oxygen homeostasis [IMP]
- protein homotetramerization [IPI]
- regulation of blood pressure [ISS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- release of cytochrome c from mitochondria [ISS]
- removal of superoxide radicals [IMP]
- response to superoxide [IMP]
- superoxide metabolic process [IDA]
- vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Peroxisomal interactome mapping enables network-based modelling of function and disease.
Peroxisomal dysfunction contributes to a broad spectrum of multisystem disorders, yet mechanistic understanding and therapeutic options remain limited, posing significant challenges for clinical management. Network-based computational strategies support hypothesis generation, biomarker discovery, and drug repurposing, but their usage is constrained by incomplete human interactome coverage-especially by scarcity of high-confidence protein-protein interaction (PPI) data for peroxisomal proteins. We present the first ... [more]
Throughput
- High Throughput
Additional Notes
- Bioluminescence resonance energy transfer (BRET)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOD2 SOD2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID