An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

O-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner.

Qiu J, Zhao R, Ma C, Wang Q, Li B, Qi Y, Pan Z, Zhao S, Wang S, Gao Z, Guo X, Qiu W, Tang W, Guo X, Deng L, Xue H, Li G

Interactions between mesenchymal glioblastoma stem cells (MES GSCs) and myeloid-derived macrophages (MDMs) shape the tumor-immunosuppressive microenvironment (TIME), promoting the progression of glioblastoma (GBM). N6-methyladenosine (m6A) plays important roles in the tumor progression. However, the mechanism of m6A in shaping the TIME of GBM remains elusive.Single-cell RNA sequencing and bulk RNA-seq datasets were employed to identify the critical role of WTAP ... [more]

Neuro Oncol May. 15, 2025; 27(4);900-915 [Pubmed: 39671515]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
WTAP DYNLL1	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Yue Y (2018)	High	-	BioGRID	2566261

Curated By

BioGRID

Interaction Summary

WTAP

Gene Ontology Biological Process

Gene Ontology Cellular Component

DYNLL1