BAIT

MSN2

stress-responsive transcriptional activator MSN2, L000001198, YMR037C

Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; relative distribution to nucleus increases upon DNA replication stress

GO Process (22)

GO Function (3)

GO Component (3)

Gene Ontology Biological Process

age-dependent response to oxidative stress involved in chronological cell aging [IGI]

cellular response to blue light [IDA]

cellular response to methylmercury [IGI, IMP]

chromatin remodeling [IGI]

positive regulation of transcription from RNA polymerase II promoter [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to acidic pH [IGI, IMP]

positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to cold [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to ethanol [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to freezing [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IGI, IMP]

positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide [IGI, IMP]

positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to increased salt [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress [IGI]

positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation [IGI]

regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction [IGI]

replicative cell aging [IGI]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA, IMP]
core promoter proximal region sequence-specific DNA binding [IDA]
sequence-specific DNA binding [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytosol [IDA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

HAP3

L000000753, YBL021C

Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding

GO Process (2)

GO Function (2)

GO Component (1)

Gene Ontology Biological Process

carbon catabolite activation of transcription from RNA polymerase II promoter [IDA]

regulation of cellular respiration [IMP]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]

Gene Ontology Cellular Component

CCAAT-binding factor complex [IDA, IPI]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

The genetic landscape of a cell.

Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, Alizadeh S, Bahr S, Brost RL, Chen Y, Cokol M, Deshpande R, Li Z, Lin ZY, Liang W, Marback M, Paw J, San Luis BJ, Shuteriqi E, Tong AH, van Dyk N, Wallace IM, Whitney JA, Weirauch MT, Zhong G, Zhu H, Houry WA, Brudno M, Ragibizadeh S, Papp B, Pal C, Roth FP, Giaever G, Nislow C, Troyanskaya OG, Bussey H, Bader GD, Gingras AC, Morris QD, Kim PM, Kaiser CA, Myers CL, Andrews BJ, Boone C

A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, ... [more]

Science Jan. 22, 2010; 327(5964);425-31 [Pubmed: 20093466]

Quantitative Score

-0.1207 [SGA Score]

Throughput

High Throughput

Ontology Terms

phenotype: colony size (APO:0000063)

Additional Notes

A Synthetic Genetic Array (SGA) analysis was carried out to quantitatively score genetic interactions based on fitness defects that were estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an SGA score of epsilon > 0.08 for positive interactions and epsilon < -0.08 for negative interactions, and a p-value < 0.05.

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
HAP3 MSN2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2010)	High	-0.1207	BioGRID	356677

Curated By

BioGRID

Interaction Summary

MSN2

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA, IMP]core promoter proximal region sequence-specific DNA binding [IDA]sequence-specific DNA binding [IDA]

Gene Ontology Cellular Component

HAP3

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]

Gene Ontology Cellular Component

Negative Genetic

Publication

The genetic landscape of a cell.

Quantitative Score

Throughput

Ontology Terms

Additional Notes

Related interactions

Curated By

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA, IMP]
core promoter proximal region sequence-specific DNA binding [IDA]
sequence-specific DNA binding [IDA]

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]