CLIC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRDX4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression.
Metabolic reprogramming is a hallmark of malignant transformation and supports tumor proliferation and survival. Chloride intracellular channel protein 1 (CLIC1) has been implicated in multiple oncogenic processes; however, its mechanistic role in regulating glycolysis in gastric cancer (GC) remains largely unknown. This study aimed to elucidate how CLIC1 modulates PKM2-dependent glycolytic metabolism and its impact on gastric tumor progression.Bioinformatic analyses ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLIC1 PRDX4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID