BRE5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SUB1
Gene Ontology Biological Process
- RNA polymerase III transcriptional preinitiation complex assembly [IDA]
- double-strand break repair via nonhomologous end joining [IMP]
- hyperosmotic response [IGI]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IPI]
- positive regulation of transcription from RNA polymerase III promoter [IDA, IGI, IMP]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription from RNA polymerase II promoter in response to stress [IDA, IGI, IMP]
- termination of RNA polymerase II transcription [IGI]
Gene Ontology Molecular Function
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
The genetic landscape of a cell.
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, ... [more]
Quantitative Score
- -0.1519 [SGA Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- A Synthetic Genetic Array (SGA) analysis was carried out to quantitatively score genetic interactions based on fitness defects that were estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an SGA score of epsilon > 0.08 for positive interactions and epsilon < -0.08 for negative interactions, and a p-value < 0.05.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BRE5 SUB1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.4226 | BioGRID | 221034 | |
| BRE5 SUB1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1752 | BioGRID | 2177718 | |
| SUB1 BRE5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3373 | BioGRID | 2161357 | |
| BRE5 SUB1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -8.7658 | BioGRID | 507757 |
Curated By
- BioGRID