BAIT
USP17L2
DUB-3, DUB3, USP17
ubiquitin specific peptidase 17-like family member 2
GO Process (20)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- CAAX-box protein processing [IMP]
- cell cycle checkpoint [IMP]
- mitotic cell cycle checkpoint [IMP]
- negative regulation of Ras GTPase activity [IDA]
- negative regulation of histone deacetylation [IMP]
- negative regulation of protein processing [IMP]
- negative regulation of protein targeting to membrane [IMP]
- positive regulation of MDA-5 signaling pathway [IMP]
- positive regulation of RIG-I signaling pathway [IMP]
- positive regulation of Rho GTPase activity [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [IMP]
- protein K63-linked deubiquitination [IDA, IMP]
- protein deubiquitination [IDA]
- regulation of apoptotic process [IMP]
- regulation of cell migration [IMP]
- regulation of cell proliferation [IMP]
- regulation of defense response to virus by host [IMP]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of ruffle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CBX1
CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta
chromobox homolog 1
GO Process (0)
GO Function (4)
GO Component (5)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Defining the human deubiquitinating enzyme interaction landscape.
Deubiquitinating enzymes (Dubs) function to remove covalently attached ubiquitin from proteins, thereby controlling substrate activity and/or abundance. For most Dubs, their functions, targets, and regulation are poorly understood. To systematically investigate Dub function, we initiated a global proteomic analysis of Dubs and their associated protein complexes. This was accomplished through the development of a software platform called CompPASS, which uses ... [more]
Cell Jul. 23, 2009; 138(2);389-403 [Pubmed: 19615732]
Quantitative Score
- 1.71 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- hek-293 cell (BTO:0000007) [epithelial cell (BTO:0000414)]
Additional Notes
- exogenous expression of bait
Curated By
- BioGRID