USP22
Gene Ontology Biological Process
- chromatin organization [TAS]
- embryo development [NAS]
- histone H4 acetylation [IDA]
- histone deubiquitination [IDA]
- histone ubiquitination [IDA]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function- H4 histone acetyltransferase activity [IDA]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, IMP]
- H4 histone acetyltransferase activity [IDA]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, IMP]
Gene Ontology Cellular Component
AASDHPPT
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Defining the human deubiquitinating enzyme interaction landscape.
Deubiquitinating enzymes (Dubs) function to remove covalently attached ubiquitin from proteins, thereby controlling substrate activity and/or abundance. For most Dubs, their functions, targets, and regulation are poorly understood. To systematically investigate Dub function, we initiated a global proteomic analysis of Dubs and their associated protein complexes. This was accomplished through the development of a software platform called CompPASS, which uses ... [more]
Quantitative Score
- 4.05 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007) [epithelial cell (BTO:0000414)]
Additional Notes
- exogenous expression of bait
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AASDHPPT USP22 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8922 | BioGRID | 1181854 | |
| AASDHPPT USP22 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9578 | BioGRID | 2250346 | |
| AASDHPPT USP22 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9747 | BioGRID | 3056281 | |
| USP22 AASDHPPT | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2719922 | |
| USP22 AASDHPPT | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID