BAIT
WDR48
P80, SPG60, UAF1
WD repeat domain 48
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
P3H1
GROS1, LEPRE1, OI8, PSEC0109
prolyl 3-hydroxylase 1
GO Process (11)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- bone development [IMP]
- chaperone-mediated protein folding [ISS]
- collagen metabolic process [ISS]
- extracellular matrix organization [TAS]
- negative regulation of cell proliferation [NAS]
- negative regulation of post-translational protein modification [IMP]
- peptidyl-proline hydroxylation [ISS]
- protein folding [IMP]
- protein hydroxylation [IMP]
- protein stabilization [IMP]
- regulation of protein secretion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Defining the human deubiquitinating enzyme interaction landscape.
Deubiquitinating enzymes (Dubs) function to remove covalently attached ubiquitin from proteins, thereby controlling substrate activity and/or abundance. For most Dubs, their functions, targets, and regulation are poorly understood. To systematically investigate Dub function, we initiated a global proteomic analysis of Dubs and their associated protein complexes. This was accomplished through the development of a software platform called CompPASS, which uses ... [more]
Cell Jul. 23, 2009; 138(2);389-403 [Pubmed: 19615732]
Quantitative Score
- 1.69 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007) [epithelial cell (BTO:0000414)]
Additional Notes
- exogenous expression of bait
Curated By
- BioGRID