SLX4
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA double-strand break processing involved in repair via single-strand annealing [IMP]
- DNA repair [IMP]
- double-strand break repair via homologous recombination [IMP]
- nucleotide-excision repair [IMP]
- positive regulation of catalytic activity [IDA]
- response to intra-S DNA damage checkpoint signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KPNA1
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [TAS]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cytokine-mediated signaling pathway [TAS]
- intracellular transport of virus [TAS]
- positive regulation of protein import into nucleus [ISS]
- regulation of DNA recombination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Structure-specific endonucleases mediate cleavage of DNA structures formed during repair of collapsed replication forks and double-strand breaks (DSBs). Here, we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx4p and D. melanogaster MUS312. Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere ... [more]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KPNA1 SLX4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3130083 |
Curated By
- BioGRID