SLX4IP
Gene Ontology Molecular Function
ERCC4
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IBA, IDA]
- DNA repair [IMP, TAS]
- double-strand break repair via homologous recombination [IMP]
- negative regulation of telomere maintenance [IMP]
- nucleotide-excision repair [IDA, IMP, TAS]
- nucleotide-excision repair involved in interstrand cross-link repair [IBA]
- nucleotide-excision repair, DNA damage removal [TAS]
- nucleotide-excision repair, DNA incision [IDA]
- nucleotide-excision repair, DNA incision, 3'-to lesion [IMP]
- nucleotide-excision repair, DNA incision, 5'-to lesion [IMP]
- resolution of meiotic recombination intermediates [IBA]
- response to UV [IMP]
- telomere maintenance [IMP]
- telomere maintenance via telomere shortening [IMP]
- transcription-coupled nucleotide-excision repair [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Structure-specific endonucleases mediate cleavage of DNA structures formed during repair of collapsed replication forks and double-strand breaks (DSBs). Here, we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx4p and D. melanogaster MUS312. Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere ... [more]
Quantitative Score
- 3.69 [Confidence Score]
Throughput
- High Throughput|Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLX4IP ERCC4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| SLX4IP ERCC4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ERCC4 SLX4IP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID