BAIT
SLX1B
GIYD2
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
GO Process (4)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UQCRC2
MC3DN5, QCR2, UQCR2
ubiquinol-cytochrome c reductase core protein II
GO Process (5)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Structure-specific endonucleases mediate cleavage of DNA structures formed during repair of collapsed replication forks and double-strand breaks (DSBs). Here, we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx4p and D. melanogaster MUS312. Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere ... [more]
Cell Jul. 10, 2009; 138(1);63-77 [Pubmed: 19596235]
Quantitative Score
- 3.01 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID