CIG1
Gene Ontology Biological Process
Gene Ontology Molecular Function
CIG2
Gene Ontology Biological Process
- negative regulation of conjugation with cellular fusion [IMP]
- negative regulation of induction of conjugation with cellular fusion [IMP]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IGI, IMP]
- positive regulation of protein serine/threonine kinase activity [IDA]
- signal transduction involved in G1 cell size control checkpoint [IGI]
- traversing start control point of mitotic cell cycle [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.
In the fission yeast Schizosaccharomyces pombe, the "start" of the cell cycle is controlled by the two functionally redundant transcriptional regulator complexes, Res1p-Cdc10p and Res2p-Cdc10p, that activate genes essential for the onset and progression of S phase. The activity of the Res2p-Cdc10p complex is regulated at least by the availability of the Rep2 trans-activator subunit in the mitotic cell cycle. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mating efficiency (APO:0000034)
- phenotype: inviable (APO:0000112)
Additional Notes
- CIG1/CIG2/PUC1/PAS1 quadruple mutants are synthetic lethal
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CIG1 CIG2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 428855 |
Curated By
- BioGRID