BAIT
PUC1
SPBP8B7.32c, SPBC19F5.01c
cyclin Puc1
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
PAS1
SPAC57A10.01, SPAC19E9.03
cyclin Pas1
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI]
- regulation of G1/S transition of mitotic cell cycle [IGI]
- regulation of L-arginine import [IGI, IMP]
- regulation of protein kinase activity [ISO]
- regulation of protein stability [NAS]
- signal transduction [IC]
- traversing start control point of mitotic cell cycle [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.
In the fission yeast Schizosaccharomyces pombe, the "start" of the cell cycle is controlled by the two functionally redundant transcriptional regulator complexes, Res1p-Cdc10p and Res2p-Cdc10p, that activate genes essential for the onset and progression of S phase. The activity of the Res2p-Cdc10p complex is regulated at least by the availability of the Rep2 trans-activator subunit in the mitotic cell cycle. ... [more]
Mol. Biol. Cell Sep. 01, 2000; 11(9);2845-62 [Pubmed: 10982385]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mating efficiency (APO:0000034)
- phenotype: inviable (APO:0000112)
Additional Notes
- CIG1/CIG2/PUC1/PAS1 quadruple mutants are synthetic lethal
Curated By
- BioGRID