BAIT
ARP8
L000003437, YOR141C
Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
FKH1
forkhead family transcription factor FKH1, L000002607, YIL131C
Forkhead family transcription factor; minor role in expression of G2/M phase genes; negatively regulates transcription elongation; positive role in chromatin silencing at HML, HMR; facilitates clustering and activation of early-firing replication origins; binds to recombination enhancer near HML, regulates donor preference during mating-type switching; relocalizes to cytosol in response to hypoxia; FKH1 has a paralog, FKH2, that arose from the whole genome duplication
GO Process (14)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- cellular response to methylmercury [IGI, IMP]
- chromatin remodeling [IGI, IMP]
- donor selection [IGI, IMP]
- mRNA 3'-end processing [IMP]
- mitochondrion organization [IBA]
- negative regulation of pseudohyphal growth [IGI]
- negative regulation of transcription elongation from RNA polymerase II promoter [IGI, IMP]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI]
- negative regulation of transcription involved in G2/M transition of mitotic cell cycle [IMP]
- positive regulation of DNA-dependent DNA replication initiation [IMP]
- positive regulation of chromatin silencing at silent mating-type cassette [IGI, IMP]
- positive regulation of transcription involved in G2/M transition of mitotic cell cycle [IGI]
- regulation of sequence-specific DNA binding transcription factor activity [IBA]
- termination of RNA polymerase II transcription [IGI, IMP]
Gene Ontology Molecular Function- DNA replication origin binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- centromeric DNA binding [IDA]
- double-stranded DNA binding [IBA]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IBA]
- DNA replication origin binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- centromeric DNA binding [IDA]
- double-stranded DNA binding [IBA]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IBA]
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Genome-wide association data reveal a global map of genetic interactions among protein complexes.
This work demonstrates how gene association studies can be analyzed to map a global landscape of genetic interactions among protein complexes and pathways. Despite the immense potential of gene association studies, they have been challenging to analyze because most traits are complex, involving the combined effect of mutations at many different genes. Due to lack of statistical power, only the ... [more]
PLoS Genet. Dec. 01, 2009; 5(12);e1000782 [Pubmed: 20041197]
Throughput
- High Throughput
Ontology Terms
- colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) analysis was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 2.0 for positive interactions (suppression) and S score < -2.5 for negative interactions (synthetic sick/lethality).
Curated By
- BioGRID