BAIT
MECP2
methyl CpG binding protein 2
GO Process (62)
GO Function (16)
GO Component (9)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- behavioral fear response [ISO]
- brain development [ISO]
- cardiolipin metabolic process [ISO]
- catecholamine secretion [ISO]
- cellular biogenic amine metabolic process [ISO]
- cerebellum development [ISO]
- chromatin silencing [ISO]
- dendrite development [ISO]
- glucocorticoid metabolic process [ISO]
- glutamine metabolic process [ISO]
- heart development [IEP]
- histone acetylation [ISO]
- histone methylation [ISO]
- inositol metabolic process [ISO]
- learning [ISO]
- long-term memory [ISO]
- long-term synaptic potentiation [ISO]
- memory [ISO]
- mitochondrial electron transport, ubiquinol to cytochrome c [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of astrocyte differentiation [IDA]
- negative regulation of histone acetylation [ISO]
- negative regulation of histone methylation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neurological system process involved in regulation of systemic arterial blood pressure [ISO]
- neuromuscular process [ISO]
- neuromuscular process controlling posture [ISO]
- neuron differentiation [ISO]
- neuron maturation [ISO]
- neuron projection development [ISO]
- pathogenesis [ISO]
- phosphatidylcholine metabolic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of synapse assembly [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- post-embryonic development [ISO]
- proprioception [ISO]
- protein localization [ISO]
- regulation of DNA methylation [IEP, IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of gene expression [ISO]
- regulation of gene expression by genetic imprinting [ISO]
- regulation of gene expression, epigenetic [ISO]
- regulation of respiratory gaseous exchange by neurological system process [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of transcription, DNA-templated [ISO]
- respiratory gaseous exchange [ISO]
- response to estradiol [IEP]
- response to hypoxia [ISO]
- response to ionizing radiation [IEP]
- response to lead ion [IEP]
- response to organic cyclic compound [IEP]
- sensory perception of pain [ISO]
- social behavior [ISO]
- startle response [ISO]
- synapse assembly [ISO]
- synaptic transmission [ISO]
- ventricular system development [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [ISO]
- double-stranded methylated DNA binding [IDA, ISO]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- histone deacetylase binding [IPI]
- mRNA binding [ISO]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- siRNA binding [ISO]
- transcription factor binding [ISO]
- unmethylated CpG binding [IDA]
- DNA binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [ISO]
- double-stranded methylated DNA binding [IDA, ISO]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- histone deacetylase binding [IPI]
- mRNA binding [ISO]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- siRNA binding [ISO]
- transcription factor binding [ISO]
- unmethylated CpG binding [IDA]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ATRX
ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX, RP5-875J14.1
alpha thalassemia/mental retardation syndrome X-linked
GO Process (15)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA damage response, signal transduction by p53 class mediator [ISS]
- DNA duplex unwinding [TAS]
- DNA methylation [TAS]
- DNA recombination [TAS]
- DNA replication-independent nucleosome assembly [IMP]
- cellular response to hydroxyurea [ISS]
- chromatin remodeling [IDA]
- negative regulation of telomeric RNA transcription from RNA pol II promoter [ISS]
- nucleosome assembly [IDA]
- positive regulation of nuclear cell cycle DNA replication [ISS]
- positive regulation of telomere maintenance [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [TAS]
- replication fork processing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.
Mutations in the human methyl-CpG-binding protein gene MECP2 cause the neurological disorder Rett syndrome and some cases of X-linked mental retardation (XLMR). We report that MeCP2 interacts with ATRX, a SWI2/SNF2 DNA helicase/ATPase that is mutated in ATRX syndrome (alpha-thalassemia/mental retardation, X-linked). MeCP2 can recruit the helicase domain of ATRX to heterochromatic foci in living mouse cells in a DNA ... [more]
Proc. Natl. Acad. Sci. U.S.A. Feb. 20, 2007; 104(8);2709-14 [Pubmed: 17296936]
Throughput
- Low Throughput
Curated By
- BioGRID