TAM41
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ART5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Identification of yeast Art5 as a multicopy suppressor for the mitochondrial translocator maintenance protein Tam41.
Normal mitochondrial protein import requires multiple translocator complexes in the outer and inner mitochondrial membrane. Tam41 is a peripheral inner membrane protein that is involved in the structural maintenance of the inner membrane translocator the TIM23 complex. Here we identified an arrestin-related protein Art5 as a multicopy suppressor for the Tam41-deficient yeast mutant, which exhibited the deteriorated TIM23 complex and ... [more]
Throughput
- Low Throughput
Ontology Terms
- heat sensitivity (APO:0000147)
Additional Notes
- Note that overexpression of ART5 (YGR068C) also suppressed the less severe growth defects of the tam41 null mutant.
- Overexpression of ART5 (YGR068C) suppressed the temperature sensitivity of the tam41-220 mutant.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ART5 TAM41 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 858169 | |
| TAM41 ART5 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 426555 |
Curated By
- BioGRID