CBL
Gene Ontology Biological Process
- cell surface receptor signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of receptor-mediated endocytosis [TAS]
- protein ubiquitination [TAS]
- regulation of transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KDR
Gene Ontology Biological Process
- angiogenesis [TAS]
- calcium-mediated signaling using intracellular calcium source [IMP]
- cell migration involved in sprouting angiogenesis [ISS]
- cellular response to vascular endothelial growth factor stimulus [IDA, IMP]
- embryonic hemopoiesis [ISS]
- endothelium development [ISS]
- extracellular matrix organization [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of endothelial cell apoptotic process [IDA]
- peptidyl-tyrosine autophosphorylation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of MAPK cascade [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of vasculogenesis [ISS]
- protein autophosphorylation [IDA]
- regulation of cell shape [IDA]
- signal transduction by phosphorylation [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IMP, TAS]
- vascular endothelial growth factor signaling pathway [IDA]
- vasculogenesis [ISS]
Gene Ontology Molecular Function- Hsp90 protein binding [TAS]
- growth factor binding [IPI]
- integrin binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor signaling protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
- Hsp90 protein binding [TAS]
- growth factor binding [IPI]
- integrin binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor signaling protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis.
Activation of phospholipase Cgamma1 (PLCgamma1) by vascular endothelial growth factor receptor-2 (VEGFR-2) in endothelial cells in part is responsible for angiogenesis in vivo. The cellular mechanisms exerting negative control over PLCgamma1 activation, however, remain unaddressed. Here by using in vitro and in vivo binding assays, we show that the Casitas B-lineage lymphoma (c-Cbl) E3 ubiquitin ligase constitutively associates with PLCgamma1 ... [more]
Throughput
- Low Throughput
Additional Notes
- not confirmed human
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CBL KDR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID