BAIT
DCR2
YLR361C
Phosphoesterase; involved in downregulation of the unfolded protein response (UPR), at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
GO Process (3)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
SFH1
L000003282, YLR321C
Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
GO Process (8)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- G2/M transition of mitotic cell cycle [IMP]
- chromatin remodeling at centromere [IMP]
- chromosome segregation [IGI]
- double-strand break repair [IMP]
- nucleosome disassembly [IDA]
- regulation of nuclear cell cycle DNA replication [IGI]
- transcription elongation from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae.
Accumulation of unfolded proteins in the endoplasmic reticulum triggers the unfolded protein response (UPR). How the UPR is downregulated is not well understood. Inositol requirement 1 (Ire1) is an endoplasmic reticulum transmembrane UPR sensor in Saccharomyces cerevisiae. When the UPR is triggered, Ire1 is autophosphorylated, on Ser 840 and Ser 841, inducing the cytosolic endonuclease activity of Ire1, thereby initiating ... [more]
EMBO Rep. Nov. 01, 2006; 7(11);1124-7 [Pubmed: 16990850]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID