An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J

Postreplicative mismatch repair (MMR) involves the concerted action of at least 20 polypeptides. Although the minimal human MMR system has recently been reconstituted in vitro, genetic evidence from different eukaryotic organisms suggests that some steps of the MMR process may be carried out by more than one protein. Moreover, MMR proteins are involved also in other pathways of DNA metabolism, ... [more]

J. Biol. Chem. Feb. 02, 2007; 282(5);2976-86 [Pubmed: 17148452]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

PMS2

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATPase activity [IBA]DNA binding [IDA]MutSalpha complex binding [IDA]protein binding [IPI]single base insertion or deletion binding [IDA]single-stranded DNA binding [IDA]

Gene Ontology Cellular Component

ATAD3A