A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.

Pidoux AL, Richardson W, Allshire RC

Fission yeast centromeres are composed of two domains: the central core and the outer repeats. Although both regions are required for full centromere function, the central core has a distinct chromatin structure and is likely to underlie the kinetochore itself, as it is associated with centromere-specific proteins. Genes placed within either region are transcriptionally silenced, reflecting the formation of a ... [more]

J. Cell Biol. Apr. 28, 2003; 161(2);295-307 [Pubmed: 12719471]

Throughput

Low Throughput

Ontology Terms

phenotype: heat sensitivity (APO:0000147)
phenotype: silencing (APO:0000046)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SIM4 CNP1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Pidoux AL (2003)	Low	-	BioGRID	246173

Curated By

BioGRID

Interaction Summary

CNP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

centromeric DNA binding [ISM]protein binding [IPI]

Gene Ontology Cellular Component

SIM4