rng5, SPCC645.05c
myosin II heavy chain
Schizosaccharomyces pombe (972h)


SPBC1734.17, SPBC1709.01
chitin synthase homolog Chs2
GO Process (0)
GO Function (2)
GO Component (3)

Gene Ontology Molecular Function

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


The fission yeast Chs2 protein interacts with the type-II myosin Myo3p and is required for the integrity of the actomyosin ring.

Martin-Garcia R, Valdivieso MH

In Schizosaccharomyces pombe cytokinesis requires the function of a contractile actomyosin ring. Fission yeast Chs2p is a transmembrane protein structurally similar to chitin synthases that lacks such enzymatic activity. Chs2p localisation and assembly into a ring that contracts during division requires the general system for polarised secretion, some components of the actomyosin ring, and an active septation initiation network. Chs2p ... [more]

J. Cell. Sci. Jul. 01, 2006; 119(0);2768-79 [Pubmed: 16772338]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • MYO2/MYO3/CHS2 tripe mutant is synthetic lethal
  • genetic complex

Curated By

  • BioGRID