A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The fission yeast Chs2 protein interacts with the type-II myosin Myo3p and is required for the integrity of the actomyosin ring.

Martin-Garcia R, Valdivieso MH

In Schizosaccharomyces pombe cytokinesis requires the function of a contractile actomyosin ring. Fission yeast Chs2p is a transmembrane protein structurally similar to chitin synthases that lacks such enzymatic activity. Chs2p localisation and assembly into a ring that contracts during division requires the general system for polarised secretion, some components of the actomyosin ring, and an active septation initiation network. Chs2p ... [more]

J. Cell. Sci. Jul. 01, 2006; 119(0);2768-79 [Pubmed: 16772338]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

MYO2/MYO3/CHS2 tripe mutant is synthetic lethal
genetic complex

Curated By

BioGRID

Interaction Summary

MYO2

Gene Ontology Biological Process

Gene Ontology Molecular Function

calcium-dependent ATPase activity [IDA]microfilament motor activity [IDA]protein binding [IPI]

Gene Ontology Cellular Component

CHS2

Gene Ontology Molecular Function

chitin synthase activity [IDA]protein binding [IPI]