BAIT
ALK
CD246, NBLST3
anaplastic lymphoma receptor tyrosine kinase
GO Process (10)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- NIK/NF-kappaB signaling [TAS]
- activation of MAPK activity [TAS]
- cell proliferation [TAS]
- neuron development [TAS]
- peptidyl-tyrosine phosphorylation [IDA, TAS]
- phosphorylation [IDA, TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- protein autophosphorylation [IDA, TAS]
- regulation of apoptotic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SOCS5
CIS6, CISH6, Cish5, SOCS-5
suppressor of cytokine signaling 5
GO Process (8)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- cell growth [NAS]
- cytokine-mediated signaling pathway [IBA, ISS]
- negative regulation of JAK-STAT cascade [IBA]
- negative regulation of T-helper 2 cell differentiation [ISS]
- negative regulation of epidermal growth factor-activated receptor activity [IDA]
- negative regulation of signal transduction [NAS]
- positive regulation of T-helper 1 cell differentiation [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of NPM-ALK interacting proteins by tandem mass spectrometry.
Constitutive overexpression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is a key oncogenic event in anaplastic large-cell lymphomas with the characteristic chromosomal aberration t(2;5)(p23;q35). Proteins that interact with ALK tyrosine kinase play important roles in mediating downstream cellular signals, and are potential targets for novel therapies. Using a functional proteomic approach, we determined the identity of proteins that interact with the ALK ... [more]
Oncogene Apr. 08, 2004; 23(15);2617-29 [Pubmed: 14968112]
Throughput
- Low Throughput
Curated By
- BioGRID