BAIT

VPS11

END1, PEP5, RNF108, hVPS11, PP3476
vacuolar protein sorting 11 homolog (S. cerevisiae)
Autophagy Project
UPS Project
GO Process (0)
GO Function (2)
GO Component (6)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

GGA3

golgi-associated, gamma adaptin ear containing, ARF binding protein 3
UPS Project
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Biochemical Activity (Ubiquitination)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability.

Yogosawa S, Kawasaki M, Wakatsuki S, Kominami E, Shiba Y, Nakayama K, Kohsaka S, Akazawa C

GGAs (Golgi-localizing, gamma-adaptin ear domain homology, ADP-ribosylation factor (ARF)-binding proteins), constitute a family of monomeric adaptor proteins and are associated with protein trafficking from the trans-Golgi network to endosomes. Here, we show that GGA3 is monoubiquitylated by a RING-H2 type-ubiquitin ligase hVPS18 (human homologue of vacuolar protein sorting 18). By in vitro ubiquitylation assays, we have identified lysine 258 in ... [more]

Biochem. Biophys. Res. Commun. Nov. 10, 2006; 350(1);82-90 [Pubmed: 16996030]

Throughput

  • Low Throughput

Curated By

  • BioGRID