PAT1
Gene Ontology Biological Process
- CENP-A containing chromatin organization [IMP]
- chromosome segregation [IMP]
- cytoplasmic mRNA processing body assembly [IGI, IMP]
- deadenylation-dependent decapping of nuclear-transcribed mRNA [IMP, IPI]
- formation of translation preinitiation complex [IMP]
- negative regulation of translational initiation [IDA, IMP]
- regulation of translational initiation [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CSL4
Gene Ontology Biological Process
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- ncRNA 3'-end processing [IC]
- nonfunctional rRNA decay [IC]
- nuclear polyadenylation-dependent mRNA catabolic process [IC]
- nuclear polyadenylation-dependent rRNA catabolic process [IMP]
- nuclear polyadenylation-dependent tRNA catabolic process [IDA]
- nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [IC]
- nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [IGI, IMP]
- nuclear-transcribed mRNA catabolic process, non-stop decay [IMP]
- polyadenylation-dependent snoRNA 3'-end processing [IC]
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation.
A key aspect of understanding eukaryotic gene regulation will be the identification and analysis of proteins that bind mRNAs and control their function. Recently, a complex of seven Lsm proteins and the Pat1p have been shown to interact with yeast mRNAs and promote mRNA decapping. In this study we present several observations to indicate that the LsmI/Pat1 complex has a ... [more]
Throughput
- Low Throughput
Ontology Terms
- heat sensitivity (APO:0000147)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CSL4 PAT1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3449 | BioGRID | 2011517 |
Curated By
- BioGRID