ACE2
Gene Ontology Biological Process
Gene Ontology Molecular Function
BUD4
Gene Ontology Biological Process
Gene Ontology Molecular Function- GTP binding [IDA, IMP]
- GTP binding [IDA, IMP]
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
ACE2, CBK1, and BUD4 in budding and cell separation.
Mutations in the RAM network genes, including CBK1, MOB2, KIC1, HYM1, and TAO3, cause defects in bud site selection, asymmetric apical growth, and mating projections. Additionally, these mutants show altered colony morphology, cell separation defects, and reduced CTS1 expression, phenotypes also seen by mutating the Ace2 transcription factor. We show that an ACE2 multicopy plasmid suppresses the latter three defects ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: colony shape (APO:0000062)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ACE2 BUD4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3224 | BioGRID | 2150945 |
Curated By
- BioGRID