TSA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
DPB11
Gene Ontology Biological Process
- DNA replication checkpoint [IMP]
- DNA replication initiation [IMP]
- double-strand break repair via break-induced replication [IMP]
- lagging strand elongation [TAS]
- leading strand elongation [TAS]
- mating type switching [IMP]
- mismatch repair [NAS]
- mitotic G2 DNA damage checkpoint [IGI]
- nucleotide-excision repair [TAS]
- positive regulation of protein phosphorylation [IDA]
- recombinational repair [IDA, IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
A biological network in Saccharomyces cerevisiae prevents the deleterious effects of endogenous oxidative DNA damage.
In this study, we used Saccharomyces cerevisiae to identify a biological network that prevents the deleterious effects of endogenous reactive oxygen species. The absence of Tsa1, a key peroxiredoxin, caused increased rates of mutations, chromosomal rearrangements, and recombination. Defects in recombinational DNA double strand break repair, Rad6-mediated postreplicative repair, and DNA damage and replication checkpoints caused growth defects or lethality ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TSA1 DPB11 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1238 | BioGRID | 2059937 |
Curated By
- BioGRID