FBH1
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- DNA recombination [IGI]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- double-strand break repair via homologous recombination [IGI]
- protein ubiquitination [IDA]
- regulation of DNA recombination [IGI]
- regulation of strand invasion [IDA]
- replication fork processing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAD2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates.
In an effort to identify novel genes involved in recombination repair, we isolated fission yeast Schizosaccharomyces pombe mutants sensitive to methyl methanesulfonate (MMS) and a synthetic lethal with rad2. A gene that complements such mutations was isolated from the S. pombe genomic library, and subsequent analysis identified it as the fbh1 gene encoding the F-box DNA helicase, which is conserved ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD2 FBH1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.8449 | BioGRID | 524992 | |
| FBH1 RAD2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | -357 | BioGRID | 299709 |
Curated By
- BioGRID