AJUBA
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- gene silencing by miRNA [IMP]
- mitotic cell cycle [TAS]
- negative regulation of hippo signaling [IDA]
- positive regulation of gene silencing by miRNA [IMP]
- positive regulation of protein complex assembly [IDA]
- regulation of cellular response to hypoxia [IDA]
- response to hypoxia [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RXRG
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling.
Corepressors play an essential role in nuclear receptor-mediated transcriptional repression. In general, corepressors directly bind to nuclear receptors via CoRNR boxes (L/I-X-X-I/V-I) in the absence of ligand and appear to act as scaffolds to further recruit chromatin remodeling complexes to specific target genes. Here, we describe the identification of the multiple LIM domain protein Ajuba as a unique corepressor for ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID