EZH2
Gene Ontology Biological Process
- DNA methylation [IMP]
- G1 to G0 transition [IMP]
- cellular response to hydrogen peroxide [IDA]
- cerebellar cortex development [IMP]
- histone H3-K27 methylation [IMP, ISO]
- histone methylation [IDA]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of epidermal cell differentiation [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of gene expression, epigenetic [ISO]
- negative regulation of retinoic acid receptor signaling pathway [ISO]
- negative regulation of striated muscle cell differentiation [IDA]
- negative regulation of transcription elongation from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of Ras GTPase activity [ISO]
- positive regulation of dendrite development [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein localization to chromatin [IMP]
- regulation of cell proliferation [IMP]
- regulation of circadian rhythm [IMP, ISO]
- regulation of gene expression [IMP]
- regulation of gliogenesis [IMP]
- regulation of neurogenesis [IMP]
- regulation of protein phosphorylation [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MTF2
Gene Ontology Biological Process
- negative regulation of histone H3-K27 methylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of histone H3-K27 methylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- segment specification [IMP]
- stem cell differentiation [IMP]
- stem cell maintenance [IMP]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Jarid2 and PRC2, partners in regulating gene expression.
The Polycomb group proteins foster gene repression profiles required for proper development and unimpaired adulthood, and comprise the components of the Polycomb-Repressive Complex 2 (PRC2) including the histone H3 Lys 27 (H3K27) methyltransferase Ezh2. How mammalian PRC2 accesses chromatin is unclear. We found that Jarid2 associates with PRC2 and stimulates its enzymatic activity in vitro. Jarid2 contains a Jumonji C ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EZH2 MTF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| MTF2 EZH2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| MTF2 EZH2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| EZH2 MTF2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| EZH2 MTF2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID