BAIT
AIRE
AIRE1, APECED, APS1, APSI, PGA1
autoimmune regulator
GO Process (4)
GO Function (7)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- chromatin binding [IDA]
- histone binding [IDA]
- protein binding [IPI]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- chromatin binding [IDA]
- histone binding [IDA]
- protein binding [IPI]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
Homo sapiens
PREY
RANBP9
BPM-L, BPM90, RANBPM, RanBP7
RAN binding protein 9
GO Process (3)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Aire's partners in the molecular control of immunological tolerance.
Aire induces the expression of a battery of peripheral-tissue self-antigens (PTAs) in thymic stromal cells, promoting the clonal deletion of differentiating T cells that recognize them. Just how Aire targets and induces PTA transcripts remains largely undefined. Screening via Aire-targeted coimmunoprecipitation followed by mass spectrometry, and validating by multiple RNAi-mediated knockdown approaches, we identified a large set of proteins that ... [more]
Cell Jan. 08, 2010; 140(1);123-35 [Pubmed: 20085707]
Throughput
- Low Throughput
Curated By
- BioGRID