POL3
Gene Ontology Biological Process
- DNA replication [IMP]
- DNA replication proofreading [IBA]
- DNA replication, removal of RNA primer [IDA]
- DNA-dependent DNA replication maintenance of fidelity [IGI]
- RNA-dependent DNA replication [IDA]
- base-excision repair, gap-filling [IBA]
- nucleotide-excision repair, DNA gap filling [IBA]
- regulation of mitotic cell cycle [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RNR4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae.
Mutation in response to most types of DNA damage is thought to be mediated by the error-prone sub-branch of post-replication repair and the associated translesion synthesis polymerases. To further understand the mutagenic response to DNA damage, we screened a collection of 4848 haploid gene deletion strains of Saccharomyces cerevisiae for decreased damage-induced mutation of the CAN1 gene. Through extensive quantitative ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mutation frequency (APO:0000198)
Additional Notes
- UV, EMS
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RNR4 POL3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1748 | BioGRID | 2045647 |
Curated By
- BioGRID