DCR1
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- RNA processing [IDA]
- cellular protein localization [IMP]
- chromatin silencing by small RNA [TAS]
- co-transcriptional gene silencing by RNA interference machinery [IMP]
- establishment of chromatin silencing at silent mating-type cassette [IMP]
- production of siRNA involved in RNA interference [IDA]
- regulation of chromatin silencing at centromere [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DIS3
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis, endonucleolytic [ISO]
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISO]
- exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISO]
- mitotic sister chromatid segregation [IMP]
- ncRNA catabolic process [ISO]
- nonfunctional rRNA decay [ISO]
- nuclear polyadenylation-dependent mRNA catabolic process [ISO]
- nuclear polyadenylation-dependent rRNA catabolic process [ISO]
- nuclear polyadenylation-dependent tRNA catabolic process [ISO]
- nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [ISO]
- nuclear-transcribed mRNA catabolic process, non-stop decay [ISO]
- positive regulation of Ran GTPase activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Dicer-independent primal RNAs trigger RNAi and heterochromatin formation.
Assembly of fission yeast pericentromeric heterochromatin and generation of small interfering RNAs (siRNAs) from noncoding centromeric transcripts are mutually dependent processes. How this interdependent positive feedback loop is first triggered is a fundamental unanswered question. Here, we show that two distinct Argonaute (Ago1)-dependent pathways mediate small RNA generation. RNA-dependent RNA polymerase complex (RDRC) and Dicer act on specific noncoding RNAs ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: rna accumulation (APO:0000224)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DIS3 DCR1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 300547 |
Curated By
- BioGRID