CSM1
Gene Ontology Biological Process
Gene Ontology Cellular Component
HMT1
Gene Ontology Biological Process
- cadmium ion import into vacuole [IMP]
- cadmium ion transmembrane transport [IMP]
- cellular response to cadmium ion [IGI, IMP]
- detoxification of cadmium ion [IMP]
- glutathione transmembrane import into vacuole [IMP]
- phytochelatin 2 import into vacuole [IMP]
- phytochelatin 3 import into vacuole [IMP]
- phytochelatin 4 import into vacuole [IMP]
- phytochelatin import into vacuole [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans.
BACKGROUND: Developing methods for protecting organisms in metal-polluted environments is contingent upon our understanding of cellular detoxification mechanisms. In this regard, half-molecule ATP-binding cassette (ABC) transporters of the HMT-1 subfamily are required for cadmium (Cd) detoxification. HMTs have conserved structural architecture that distinguishes them from other ABC transporters and allows the identification of homologs in genomes of different species including ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: metal resistance (APO:0000090)
- phenotype: vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HMT1 CSM1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 480254 |
Curated By
- BioGRID