BAIT
KDM5B
CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A
lysine (K)-specific demethylase 5B
GO Process (3)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CACNA1H
CACNA1HB, Cav3.2, ECA6, EIG6
calcium channel, voltage-dependent, T type, alpha 1H subunit
GO Process (14)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- aldosterone biosynthetic process [IMP]
- axon guidance [TAS]
- calcium ion import [IDA]
- cellular response to hormone stimulus [IEP]
- cellular response to potassium ion [IEP]
- cortisol biosynthetic process [IMP]
- membrane depolarization during action potential [IBA]
- muscle contraction [TAS]
- muscle organ development [NAS]
- myoblast fusion [TAS]
- positive regulation of acrosome reaction [IMP]
- regulation of heart contraction [TAS]
- regulation of membrane potential [IDA]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.
JARID1B (jumonji AT rich interactive domain 1B) is a large nuclear protein that is highly expressed in breast cancers and is proposed to function as a repressor of gene expression. In this paper, a phage display screen using the N-terminus of JARID1B as bait identified one of the JARID1B interacting proteins, namely PcG protein (Polycomb group) hPc2. We demonstrated that ... [more]
BMB Rep Mar. 31, 2009; 42(3);154-9 [Pubmed: 19336002]
Throughput
- Low Throughput
Curated By
- BioGRID