BAIT
KDM5B
CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A
lysine (K)-specific demethylase 5B
GO Process (3)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
DGKQ
DAGK, DAGK4, DAGK7
diacylglycerol kinase, theta 110kDa
GO Process (8)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.
JARID1B (jumonji AT rich interactive domain 1B) is a large nuclear protein that is highly expressed in breast cancers and is proposed to function as a repressor of gene expression. In this paper, a phage display screen using the N-terminus of JARID1B as bait identified one of the JARID1B interacting proteins, namely PcG protein (Polycomb group) hPc2. We demonstrated that ... [more]
BMB Rep Mar. 31, 2009; 42(3);154-9 [Pubmed: 19336002]
Throughput
- Low Throughput
Curated By
- BioGRID