BAIT
BCOR
ANOP2, MAA2, MCOPS2
BCL6 corepressor
GO Process (11)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- heart development [IMP]
- histone H2A monoubiquitination [IDA]
- negative regulation of bone mineralization [IMP]
- negative regulation of histone H3-K36 methylation [IMP]
- negative regulation of histone H3-K4 methylation [IMP]
- negative regulation of tooth mineralization [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- odontogenesis [IMP]
- palate development [IMP]
- specification of axis polarity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPA4
APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
heat shock 70kDa protein 4
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.
The corepressor BCOR potentiates transcriptional repression by the proto-oncoprotein BCL6 and suppresses the transcriptional activity of a common mixed-lineage leukemia fusion partner, AF9. Mutations in human BCOR cause male lethal, X-linked oculofaciocardiodental syndrome. We identified a BCOR complex containing Polycomb group (PcG) and Skp-Cullin-F-box subcomplexes. The PcG proteins include RING1, RYBP, NSPC1, a Posterior Sex Combs homolog, and RNF2, an ... [more]
Mol. Cell. Biol. Sep. 01, 2006; 26(18);6880-9 [Pubmed: 16943429]
Throughput
- Low Throughput
Curated By
- BioGRID