SLC6A3
Gene Ontology Biological Process
- adenohypophysis development [ISO]
- aging [IEP]
- cation transmembrane transport [IDA, ISO]
- dopamine biosynthetic process [ISO]
- dopamine catabolic process [ISO]
- dopamine transport [IDA, ISO]
- lactation [ISO]
- locomotory behavior [ISO]
- monoamine transport [ISO]
- positive regulation of multicellular organism growth [ISO]
- prepulse inhibition [ISO]
- regulation of dopamine metabolic process [ISO]
- response to cAMP [IDA]
- response to cocaine [ISO]
- response to drug [IEP]
- response to ethanol [IDA]
- response to iron ion [IEP]
- response to nicotine [IEP]
- response to organic cyclic compound [IEP]
- sensory perception of smell [ISO]
Gene Ontology Molecular Function- dopamine binding [ISO]
- dopamine transmembrane transporter activity [IDA, ISO]
- dopamine:sodium symporter activity [IDA]
- drug binding [IDA]
- monoamine transmembrane transporter activity [ISO]
- protease binding [IPI]
- protein N-terminus binding [ISO]
- protein complex binding [IDA]
- protein phosphatase 2A binding [IPI]
- receptor binding [IPI]
- dopamine binding [ISO]
- dopamine transmembrane transporter activity [IDA, ISO]
- dopamine:sodium symporter activity [IDA]
- drug binding [IDA]
- monoamine transmembrane transporter activity [ISO]
- protease binding [IPI]
- protein N-terminus binding [ISO]
- protein complex binding [IDA]
- protein phosphatase 2A binding [IPI]
- receptor binding [IPI]
Gene Ontology Cellular Component
NEDD4
Gene Ontology Biological Process
- T cell activation [ISO]
- adaptive immune response [ISO]
- blood vessel morphogenesis [ISO]
- cellular response to UV [ISO]
- development involved in symbiotic interaction [ISO]
- endocardial cushion development [ISO]
- glucocorticoid receptor signaling pathway [ISO]
- immune response [IEP]
- lysosomal transport [ISO]
- negative regulation of sodium ion transport [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISO, ISS]
- neuromuscular junction development [ISO]
- neuron projection development [ISO]
- outflow tract morphogenesis [ISO]
- positive regulation of nucleocytoplasmic transport [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein catabolic process [ISO]
- progesterone receptor signaling pathway [ISO]
- protein K63-linked ubiquitination [IDA]
- protein monoubiquitination [ISO]
- protein targeting to lysosome [ISO]
- protein ubiquitination [ISO, ISS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, ISO]
- receptor catabolic process [ISO]
- receptor internalization [ISO]
- regulation of dendrite morphogenesis [IDA, ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane potential [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- regulation of synapse organization [ISO]
- response to denervation involved in regulation of muscle adaptation [IEP]
- transmission of virus [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
Gene Ontology Molecular Function- RNA polymerase binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- phosphoserine binding [ISO]
- phosphothreonine binding [ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sodium channel inhibitor activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- RNA polymerase binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- phosphoserine binding [ISO]
- phosphothreonine binding [ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sodium channel inhibitor activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis.
The function of the dopamine transporter (DAT) to terminate dopamine neurotransmission is regulated by endocytic trafficking of DAT. To elucidate the mechanisms of DAT endocytosis, we generated a fully functional mutant of the human DAT in which a hemagglutinin epitope (HA) was incorporated into the second extracellular loop. The endocytosis assay, based on the uptake of an HA antibody, was ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID