BAIT

HTT

HD, IT15
huntingtin
Alzheimer's Disease Project
Homo sapiens
PREY

CIT2

citrate (Si)-synthase CIT2, L000000342, YCR005C
Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
GO Process (3)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein.

Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ

Genome-wide screens were performed in yeast to identify genes that enhance the toxicity of a mutant huntingtin fragment or of alpha-synuclein. Of 4850 haploid mutants containing deletions of nonessential genes, 52 were identified that were sensitive to a mutant huntingtin fragment, 86 that were sensitive to alpha-synuclein, and only one mutant that was sensitive to both. Genes that enhanced toxicity ... [more]

Science Dec. 05, 2003; 302(5651);1769-72 [Pubmed: 14657499]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • deletion of the yeast gene enhances toxicity of the human huntington HD53Q allele in a yeast background

Curated By

  • BioGRID