EGFR
Gene Ontology Biological Process
- activation of MAPKK activity [ISO]
- astrocyte activation [ISO]
- cell morphogenesis [IGI]
- cell proliferation [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular response to amino acid stimulus [IDA]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to estradiol stimulus [ISO]
- cerebral cortex cell migration [IMP]
- digestive tract morphogenesis [IMP]
- embryonic placenta development [IMP]
- epidermal growth factor receptor signaling pathway [IDA, IGI, IMP, ISO]
- epidermis development [IMP]
- hair follicle development [IMP]
- intracellular signal transduction [ISO]
- learning or memory [ISO]
- magnesium ion homeostasis [ISO]
- morphogenesis of an epithelial fold [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein catabolic process [ISO]
- neuron projection morphogenesis [ISO]
- ovulation cycle [ISO]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IDA, IGI, ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of epithelial cell proliferation [IMP, ISO]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of inflammatory response [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of superoxide anion generation [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vasoconstriction [ISO]
- positive regulation of vasodilation [ISO]
- protein autophosphorylation [IDA, ISO]
- regulation of cell proliferation [IGI]
- regulation of nitric-oxide synthase activity [ISO]
- regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- response to UV-A [ISO]
- response to calcium ion [ISO]
- salivary gland morphogenesis [IMP]
- signal transduction [IDA, ISO]
- single organismal cell-cell adhesion [ISO]
- translation [ISO]
Gene Ontology Molecular Function- actin filament binding [ISO]
- chromatin binding [ISO]
- enzyme binding [ISO]
- epidermal growth factor binding [ISO]
- epidermal growth factor-activated receptor activity [IDA, ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- kinase activity [IDA]
- nitric-oxide synthase regulator activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [ISO]
- signal transducer activity [IDA]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- actin filament binding [ISO]
- chromatin binding [ISO]
- enzyme binding [ISO]
- epidermal growth factor binding [ISO]
- epidermal growth factor-activated receptor activity [IDA, ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- kinase activity [IDA]
- nitric-oxide synthase regulator activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [ISO]
- signal transducer activity [IDA]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- apical plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO]
- cell surface [IDA, ISO]
- cytoplasm [ISO]
- endocytic vesicle [IDA, ISO]
- endosome [ISO]
- endosome membrane [ISO]
- focal adhesion [ISO]
- intracellular [IDA]
- membrane [ISO]
- membrane raft [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
PARK2
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- aggresome assembly [IMP]
- cellular protein catabolic process [IMP]
- cellular response to dopamine [TAS]
- cellular response to manganese ion [TAS]
- cellular response to toxic substance [IMP]
- cellular response to unfolded protein [TAS]
- central nervous system development [TAS]
- dopamine metabolic process [TAS]
- mitochondrial fission [ISS]
- mitochondrion degradation [IMP, ISS]
- mitochondrion organization [ISS]
- negative regulation of JNK cascade [ISS]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell death [IDA]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of glucokinase activity [IDA]
- negative regulation of insulin secretion [IDA]
- negative regulation of mitochondrial fusion [ISS]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [IGI]
- negative regulation of oxidative stress-induced cell death [NAS, TAS]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of reactive oxygen species metabolic process [IGI]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- neuron cellular homeostasis [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of mitochondrial fission [ISS]
- positive regulation of mitochondrial fusion [IMP]
- positive regulation of proteasomal protein catabolic process [IGI]
- positive regulation of protein linear polyubiquitination [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K27-linked ubiquitination [TAS]
- protein K29-linked ubiquitination [TAS]
- protein K48-linked ubiquitination [IDA]
- protein K6-linked ubiquitination [TAS]
- protein K63-linked ubiquitination [IDA, TAS]
- protein autoubiquitination [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IC, IDA, NAS, TAS]
- regulation of autophagy [IDA]
- regulation of cellular response to oxidative stress [ISS]
- regulation of dopamine secretion [TAS]
- regulation of glucose metabolic process [TAS]
- regulation of lipid transport [TAS]
- regulation of mitochondrion degradation [TAS]
- regulation of mitochondrion organization [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of synaptic vesicle transport [NAS]
- response to endoplasmic reticulum stress [IMP]
- response to oxidative stress [ISS]
- zinc ion homeostasis [ISS]
Gene Ontology Molecular Function- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling.
Mutations in the parkin gene are responsible for a common familial form of Parkinson's disease. As parkin encodes an E3 ubiquitin ligase, defects in proteasome-mediated protein degradation are believed to have a central role in the pathogenesis of Parkinson's disease. Here, we report a novel role for parkin in a proteasome-independent ubiquitination pathway. We have identified a regulated interaction between ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID